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Bio Tool #29 · SOL Review · Biology Unit 9 · SOL BIO.4a–e

Living Cell or Hijacker? Bacteria and Viruses for the Biology SOL

About five questions on the Biology SOL come from bacteria and viruses. Nearly every one turns on a single difference: a bacterium is a living cell that runs itself, and a virus is a packet of genes that can do nothing until it gets inside a cell.

Three questions, cold

Answer these before anything else and keep your score. You will try the same three again at the end.

Start the three questions

The five ideas behind most bacteria & viruses questions

Idea 1BIO.4a · BIO.4c

A bacterium is a cell; a virus is genes in a protein coat

A bacterium is a single prokaryotic cell: membrane, cell wall, ribosomes, a loop of DNA, no nucleus. It eats, grows and divides on its own. A virus has only genetic material (DNA or RNA) inside a protein coat called a capsid, sometimes wrapped in an envelope. It has no ribosomes and no metabolism, so it is usually called nonliving. Outside a cell it does nothing at all.

On the test
If something grows in plain nutrients, it is alive, likely a bacterium. If it increases only when living cells are present, it is a virus.
Draw it
Draw a bacterium and a virus side by side and label every part. Make the virus far smaller: a typical bacterium is about ten times wider than a typical virus.
Check it
3 practice questions on this idea
Idea 2BIO.4b · BIO.4c

A virus copies itself by taking over a host cell, fast or slow

A virus attaches only to cells whose surface fits its attachment proteins, which is why a dog virus cannot infect its owner. Its genes get inside, and the cell's own ribosomes and enzymes build new viral parts. In the lytic cycle the new viruses assemble and burst out, usually killing the cell. In the lysogenic cycle the viral DNA joins the host's DNA and is copied every time the cell divides, until a trigger switches it to the lytic cycle.

On the test
Order questions follow attach → genes enter → host builds parts → assemble → release. A delay before any new viruses appear means lysogenic.
Draw it
Draw a circle for the lytic cycle with five steps around it. Off step 2, draw a side loop where the viral DNA joins the chromosome and the cell divides twice, then an arrow back into the circle.
Check it
3 practice questions on this idea
Idea 3BIO.4b · BIO.4c

Bacteria double by binary fission and get energy three ways

Most bacteria reproduce asexually by binary fission: copy the DNA, split in two. Each division doubles the population, so one cell dividing every 20 minutes becomes 64 in two hours. Bacteria also differ in how they get energy: some make food from light (photoautotrophs), some from chemicals (chemoautotrophs), and many take in organic matter (heterotrophs).

On the test
Growth questions are doubling questions: count the divisions, then double that many times. Don't add.
Draw it
Draw one cell at the top of a tree, then 2, 4, 8, 16. Mark each row “+20 min.”
Check it
2 practice questions on this idea
Idea 4BIO.4d

Most bacteria help, and some viruses do too

A few bacteria and many viruses cause disease, but most bacteria are helpful or harmless. Bacteria decompose dead matter and return nutrients to the soil, fix nitrogen from the air for plants, help digest food in your gut, and turn milk into yogurt and cheese. Viruses that infect bacteria, called bacteriophages, keep bacterial populations in check and are being used to treat infections antibiotics cannot.

On the test
Choices that say all bacteria are harmful, or that every disease comes from bacteria, are wrong. Experiments with a sterilized control are asking you what the living microbes did.
Draw it
Draw a leaf on the soil with bacteria around it, a bean root with nodules, and a gut. Label each with the job the bacteria do there.
Check it
4 practice questions on this idea
Idea 5BIO.4e

Germ theory explains infection, and each tool has one job

Germ theory says many diseases are caused by microorganisms. Evidence such as the drop in deaths when doctors began washing their hands led to sanitation, safe food and water, and sterile technique. A vaccine prepares the immune system ahead of time, so memory cells respond fast if the real pathogen arrives. An antibiotic kills bacteria that are already causing an infection and does nothing to a virus. Stopping an antibiotic early, against the doctor's directions, leaves survivors that are more likely to be resistant.

On the test
Vaccine = prevent, before exposure. Antibiotic = cure a bacterial infection. Antibiotics for the flu or a cold is always a wrong answer.
Draw it
Draw a graph of immune response against time with two bumps: a small, slow one after the vaccine and a tall, fast one at the second exposure. Label the second bump “memory.”
Check it
5 practice questions on this idea

Taking apart an SOL question in four moves

  1. Read the last line first. It tells you what kind of answer you are hunting for: a cause, a conclusion, an order, a relationship.
  2. Mark the evidence. Circle the numbers in the table or the change in the graph. The right answer always agrees with them.
  3. Cross out the traps. In this unit they sound like: all bacteria, antibiotics for a virus, a vaccine cures, viruses are cells.
  4. Pick the answer that names a mechanism and say it in one sentence before you tap it.

In the two-sample question, the last line asks which conclusion fits. The table shows X grew in broth alone and Y grew only when living cells were added. Only a living cell can grow on nutrients alone, and only a virus needs a host, so X is the bacterium and Y is the virus. The other choices fail on one row of the table each. Try that one.

Practice with every answer explained

Each question tells you why the right answer is right, why the one you picked is not, and where the idea lives in the standards. Nothing is submitted, and your answers stay on your device.

All 17 bacteria & viruses practice questions Challenge questions 50–52 and 56 on microbes The three warm-up questions again

What to practice next, and why

The Biology SOL has 45 scored questions spread across ten units. After this one, these are the best uses of your time, in order.

Virginia also posts its released Biology test so students can practice in the same TestNav system the real test uses. Find it on the Virginia Department of Education's SOL practice items page, then come back here to study whatever you miss.

Every unit, with a practice link for each: SOL Review Sessions.

For teachers: running it in 45 minutes

The paper version prints on two pages: the five ideas with a box to draw in, six practice questions without answers, and a plan for what to study next, with a QR code back here. Students without a device can do the whole session on paper; the explanations are online for later. Practice questions are original and written from the Virginia 2018 Biology Standards of Learning and the VDOE Instructional Guide; they are not produced or endorsed by the Virginia Department of Education.